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Literatur
Behandelte Artikel
Pharmakokinetik und Pharmakodynamik
King, M., Su, W., Chang, A., Zuckerman, A. and Pasternak, G.W. (2001) Transport of opioids from the brain to the periphery by P-glycoprotein: peripheral actions of central drugs. Nat Neurosci, 4, 268-274.
Das Neuron: Synaptische Transmission und Neurotransmitter
Maldonado, R., Saiardi, A., Valverde, O., Samad, T.A., Roques, B.P. and Borrelli, E. (1997) Absence of opiate rewarding effects in mice lacking dopamine D2 receptors. Nature, 388, 586-589.
Chase, D.L., Pepper, J.S. and Koelle, M.R. (2004) Mechanism of extrasynaptic dopamine signaling in Caenorhabditis elegans. Nat Neurosci, 7, 1096-1103.
Koffein, Nikotin
Tapper, A.R., McKinney, S.L., Nashmi, R., Schwarz, J., Deshpande, P., Labarca, C., Whiteaker, P., Marks, M.J., Collins, A.C. and Lester, H.A. (2004) Nicotine activation of alpha4* receptors: sufficient for reward, tolerance, and sensitization. Science, 306, 1029-1032.
Lindskog, M., Svenningsson, P., Pozzi, L., Kim, Y., Fienberg, A.A., Bibb, J.A., Fredholm, B.B., Nairn, A.C., Greengard, P. and Fisone, G. (2002) Involvement of DARPP-32 phosphorylation in the stimulant action of caffeine. Nature, 418, 774-778.
Kokain und Amphetamine
McClung, C.A. and Nestler, E.J. (2003) Regulation of gene expression and cocaine reward by CREB and DeltaFosB. Nat Neurosci, 6, 1208-1215.
Nestler, E.J. (2004) Historical review: Molecular and cellular mechanisms of opiate and cocaine addiction. Trends Pharmacol Sci, 25, 210-218.
Nestler, E.J. (2002) From neurobiology to treatment: progress against addiction. Nat Neurosci, 5 Suppl, 1076-1079.
Opiate
He, L., Fong, J., von Zastrow, M. and Whistler, J.L. (2002) Regulation of opioid receptor trafficking and morphine tolerance by receptor oligomerization. Cell, 108, 271-282.
Drogenmissbrauch: Abhängigkeit als chronische Krankheit
Hutcheson, D.M., Everitt, B.J., Robbins, T.W. and Dickinson, A. (2001) The role of withdrawal in heroin addiction: enhances reward or promotes avoidance? Nat Neurosci, 4, 943-947.
Tetrahydrocannabinol
Jordt, S.E., Bautista, D.M., Chuang, H.H., McKemy, D.D., Zygmunt, P.M., Hogestatt, E.D., Meng, I.D. and Julius, D. (2004) Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1. Nature, 427, 260-265.
Mato, S., Chevaleyre, V., Robbe, D., Pazos, A., Castillo, P.E. and Manzoni, O.J. (2004) A single in-vivo exposure to delta 9THC blocks endocannabinoid-mediated synaptic plasticity. Nat Neurosci, 7, 585-586.
Ethanol
Sillaber, I., Rammes, G., Zimmermann, S., Mahal, B., Zieglgansberger, W., Wurst, W., Holsboer, F. and Spanagel, R. (2002) Enhanced and delayed stress-induced alcohol drinking in mice lacking functional CRH1 receptors. Science, 296, 931-933.
Corl, A.B., Rodan, A.R. and Heberlein, U. (2005) Insulin signaling in the nervous system regulates ethanol intoxication in Drosophila melanogaster. Nat Neurosci, 8, 18-19.
Antidepressiva und Benzodiazepine
Santarelli, L., Saxe, M., Gross, C., Surget, A., Battaglia, F., Dulawa, S., Weisstaub, N., Lee, J., Duman, R., Arancio, O., Belzung, C. and Hen, R. (2003) Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants. Science, 301, 805-809.
Rudolph, U., Crestani, F., Benke, D., Brunig, I., Benson, J.A., Fritschy, J.M., Martin, J.R., Bluethmann, H. and Mohler, H. (1999) Benzodiazepine actions mediated by specific gamma-aminobutyric acid(A) receptor subtypes. Nature, 401, 796-800.
Halluzinogene
Ricaurte, G.A., Yuan, J., Hatzidimitriou, G., Cord, B.J. and McCann, U.D. (2002) Severe dopaminergic neurotoxicity in primates after a common recreational dose regimen of MDMA ("ecstasy"). Science, 297, 2260-2263.
Ricaurte, G.A., Yuan, J., Hatzidimitriou, G., Cord, B.J. and McCann, U.D. (2003) Retraction. Science, 301, 1479.
Check, E. (2004) Psychedelic drugs: the ups and downs of ecstasy. Nature, 429, 126-128.
Weiterführende Literatur und Informationsquellen
Julien, R. M.. A Primer of Drug Action, 10. Auflage, Worth Publishing (2005); auf Deutsch erschienen als Drogen und Psychopharmaka, Spektrum Verlag (1997).
Mutschler, E. et al. Arzneimittelwirkungen - Lehrbuch der Pharmakologie & Toxikologie, 8. Auflage, Wissenschaftliche Verlagsgesellschaft mbH Stuttgart (2001)
Kolb, B. & Whishaw, I.Q. Neuropsychologie, 2.Auflage, Spektrum Verlag (1996)
www.medicine-worldwide.de, www.medizinfo.de, www.praevention.at,
www.drug-infopool.de, www.planet-wissen.de, www.quarks.de.
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